Job Description

Job Title: Cell Line Development Research Associate Location: Philadelphia, Pennsylvania Type: Contract Contractor Work Model: Onsite Job Description: Cell Line Development Research Associate is involved in the creation of stable cell lines for the recombinant adeno-associated viral vector (rAAV) production processes . He/she executes experiments, produces relevant documentation, and works under supervision. He/she will be responsible for: • Culturing mammalian cells for viral production in shake flasks, spinner flasks, spin tubes, deep well and automation platforms. • Performing experiments in the development, optimization and scale-up of AAV producer cell lines. • Preparing process development protocols, data analysis summaries, technical reports, and other relevant process documentation. • Optimization of transfection and transduction protocols for newly engineered cell lines. • Maintaining an accurate laboratory notebook. • Ensuring work conforms to applicable quality and safety standards. • Participating on project teams (as needed). Education and Experience Requirements B.S. with 3-6 years of experience, MS.c with 2-5 years of relevant scientific or technical experience in the life sciences industry or equivalent • Experience in cell culture including materials, instruments and technologies is essential. • Experience with viral vector production is preferred . Key Skills, Abilities, and Competencies: Hands-on experience in mammalian cell culture production processes is a critical requirement. This includes small scale (shaker flasks, spinner flasks, spin tubes, deep well) and/or benchtop bioreactor scale. Experience with creation, analysis and characterization of new engineered cell lines and stability studies (subcloning, clonal expansion, transient transfection and expression screening) is a strong plus. Experience in molecular biology techniques (plasmid design, molecular cloning, SDS-PAGE/western blotting, qPCR, etc) is a strong plus. Automation and ELN experience is a strong plus. Effective communication skills (verbal, written, interpersonal). Industry experience is a plus but not required Basic Knowledge on AAV biology is a plus. Must be able to interact with cross-functional teams. Analytical and problem-solving skills. Ability to manage time effectively. Experience in laboratory automation hardware and software is a plus. Teamwork is a must. Must be able to lift 25 pounds. • Due to the inherent nature of cell culture, some weekend work and/or work on holidays may be needed. On occasion, long work hours may be required depending upon the experiment schedule. • Handling large volumes of cell culture or related materials, such as tens of liters, may be required. Also, several viral materials, including AAV may be involved in the work. System One, and its subsidiaries including Joulé, ALTA IT Services, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan. System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law. Ref: #558-Scientific

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